The purpose of this study is to evaluate the effectiveness of High Frequency (10kHz) Spinal Cord Stimulation in patients with chronic Chemotherapy-Induced Peripheral Neuropathy

Aims: to document the efficacy and safety outcomes of SCS in persons with chronic, chemotherapy-induced peripheral neuropathy Types of chemotherapy: Taxotere, Oxaliplatin, Paclitaxel Primary outcome measure: % responder rate at …

CONDITION: Cancer

GENDER: Both males and females

AGE GROUP: 18 to 100 years

TRIAL STATUS: Recruiting

The MothersBabies Study

What is the study about? Are you interested in finding out how our microbiome (the DNA of all the ‘bugs’ that live on us and in us) can impact on …

CONDITION: Reproductive Health and Childbirth

GENDER: Females

AGE GROUP: 18 and above

TRIAL STATUS: Recruiting

EXTEND-IA DNase: Improving early reperfusion with adjuvant dornase alfa in large vessel ischemic stroke

Patients presenting to the emergency department with acute ischemic stroke, who are are eligible for standard intravenous thrombolytic therapy within 4.5 hours of stroke onset will be assessed for major …

CONDITION: Stroke

GENDER: Both males and females

AGE GROUP: 18 and above

TRIAL STATUS: Recruiting

COVID-19 and influenza combination vaccine

ARE YOU AGED BETWEEN 50 and 80 YEARS OLD? ARE YOU FULLY VACCINATED AGAINST COVID-19 (with or without a booster)? You may qualify* to take part in a trial for …

CONDITION: Other

GENDER: Both males and females

AGE GROUP: 50 to 80 years

TRIAL STATUS: Completed

Extending the Time Window for Tenecteplase by Effective Reperfusion in Patients With Large Vessel Occlusion (ETERNAL-LVO)

Patients presenting to the emergency department with an acute ischemic stroke due to a large vessel occlusion eligible for thrombectomy and target mismatch on computed tomography perfusion imaging within 24 …

CONDITION: Stroke

GENDER: Both males and females

AGE GROUP: 18 and above

TRIAL STATUS: Recruiting

CHEWY Trial: A multi-centre randomized non-inferiority trial of chewing gum versus ondansetron to treat postoperative nausea and vomiting in female patients after breast or laparoscopic surgery.

One stick of sugar-free peppermint-flavoured chewing gum (Wrigley’s Extra Sugarfree Gum, Wrigley Company) in the event of nausea, retching and/or vomiting occurring in the post anaesthesia care unit (PACU) after …

CONDITION: Anaesthesiology

GENDER: Females

AGE GROUP: 12 and above

TRIAL STATUS: Recruiting

Volatile Anaesthesia and Perioperative Outcomes Related to Cancer: The VAPOR-C Trial

VAPOR-C is a randomised study of the impact of IV versus inhaled anaesthesia (propofol versus sevoflurane) and lidocaine versus no lidocaine on duration of disease free survival inpatients with either …

CONDITION: Anaesthesiology

GENDER: Both males and females

AGE GROUP: 18 and above

TRIAL STATUS: Recruiting

A clinical study in individuals with Amyotrophic Lateral Sclerosis (ALS)

About this clinical trial: Wesley Medical Research is seeking research participants for a study evaluating the safety and tolerability of an investigational drug for Amyotrophic lateral sclerosis (ALS) and how …

CONDITION: Neurological

GENDER: Both males and females

AGE GROUP: 18 to 75 years

TRIAL STATUS: Recruiting

Do you have non-alcoholic steatohepatitis (NASH)?

Australian researchers are testing a new treatment for non-alcoholic steatohepatitis (NASH), an advanced form of non-alcoholic fatty liver disease (NAFLD). A new medication is to be taken orally 3 times …

CONDITION: Inflammatory and Immune System

GENDER: Both males and females

AGE GROUP: 18 and above

TRIAL STATUS: Active, not recruiting

EAGLE-1 – treatment of urogenital gonorrhoea

Have you been recently diagnosed with uncomplicated urogenital Gonorrhoea? Or do you have urogenital discharge and haven’t been treated yet? A new treatment might be available to you.​

CONDITION: Reproductive Health and Childbirth

GENDER: Both males and females

AGE GROUP: 18 and above

TRIAL STATUS: Recruiting

Bacterial Vaginosis

If you: Are a female between 18-45 years old Are symptomatic of BV Have not been treated with Antibiotics yet You may be eligible to take part in a research …

CONDITION: Other

GENDER: Females

AGE GROUP: 18 to 45 years

TRIAL STATUS: Recruiting

ONLINE: Yoga and mental health in cancer study

*** This trial is conducted online *** Psychological distress in people diagnosed with cancer is common and can have a number of negative consequences for affected people, including a reduced …

CONDITION: Mental Health

GENDER: Females

AGE GROUP: 18 and above

TRIAL STATUS: Recruiting

ABI-2280-303

Treating female patients with cervical squamous intraepithelial lesions (SIL), including both low grade and high grade lesions

CONDITION: Other

GENDER: Females

AGE GROUP: 25 to 55 years

TRIAL STATUS: Recruiting

Clinical trial of Sailuotong (SLT) for Vascular Dementia or Alzheimer’s Disease with evidence of cerebrovascular disease

SLT for Vascular Dementia Vascular dementia (VaD) is the second major cause of dementia accounting for 15-20 per cent of all dementia cases. VaD is an acquired cognitive impairment due …

CONDITION: Neurological

GENDER: Both males and females

AGE GROUP: 40 and above

TRIAL STATUS: Active, not recruiting

RIPC

Project Title: Role of Sympathetic Activation in Ischemia Reperfusion Injury   The aim of the study is to investigate the effectiveness of remote ischemic preconditioning (RIPC) in healthy male individuals. …

CONDITION: Cardiovascular

GENDER: Males

AGE GROUP: 60 to 75 years

TRIAL STATUS: Recruiting

MODUS

Project Title: Multi-Organ Denervation to Reduce Sympathetic Drive   The purpose of this research study is to evaluate the safety of liver denervation, kidney denervation and a combination of both …

CONDITION: Cardiovascular

GENDER: Both males and females

AGE GROUP: 22 to 70 years

TRIAL STATUS: Recruiting

SPYRAL HTN-ON-MED Study

Project Title: Global Clinical Study of Renal Denervation with the Symplicity SPYRALTM multi-electrode renal denervation system in Patients with Uncontrolled Hypertension on Standard Medical Therapy In some individuals with hypertension, …

CONDITION: Cardiovascular

GENDER: Both males and females

AGE GROUP: 20 to 80 years

TRIAL STATUS: Recruiting

Hidradenitis Suppurativa (Acne Inversa) Clinical Trial

An Australian researcher is testing an investigational product (Hidracare). In this study, we are trying to find out if Hidracare solution, a salt mixture, could improve the skin condition Hidradentitis …

CONDITION: Skin

GENDER: Both males and females

AGE GROUP: 18 and above

TRIAL STATUS: Completed

MINIHT

Project Title: The Role of Neuroinflammation in Hypertension – Minocycline for Resitant for Hypertension: A Randomised, double-blind, placebo-controlled trial   The objective of this study is to establish whether or …

CONDITION: Cardiovascular

GENDER: Both males and females

AGE GROUP: 45 to 65 years

TRIAL STATUS: Recruiting

EMPA

Project Title: Effects of SGLT-2 inhibition on Sympathetic Nervous System Activity in Humans   This research study aims to assess whether Jardiance® (otherwise known as Empagliflozin), a medication approved for …

CONDITION: Cardiovascular

GENDER: Both males and females

AGE GROUP: 25 to 65 years

TRIAL STATUS: Recruiting

Obesity Hypertension

Project Title: Sympathoinhibition as a preferred second line treatment of obesity related hypertension This research study aims to optimise the treatment of hypertension in individuals with obesity. It will compare …

CONDITION: Cardiovascular

GENDER: Both males and females

AGE GROUP: 25 to 70 years

TRIAL STATUS: Recruiting

ReActiv8 Observational Registry

CONDITION: Other

GENDER: Both males and females

AGE GROUP: 18 to 65 years

TRIAL STATUS: Recruiting

New trial into treatment of silicosis, asbestosis, black lung (or coal workers pneumoconiosis) and other dust diseases (the NiPS or Nintedanib in Pneumoconiosis Trial)

OVERVIEW The Holdsworth House Research team are currently looking for study participants who suffer from dust-related fibrotic respiratory diseases, such as coal workers pneumoconiosis (CWP, or Black Lung), silicosis, diffuse …

CONDITION: Respiratory

GENDER: Both males and females

AGE GROUP: 18 and above

TRIAL STATUS: Recruiting

Do you experience UTIs?

OVERVIEW The Holdsworth House Research team are currently looking for study participants who suffer from Urinary Tract Infections (UTIs). We are investigating a new potential treatment for acute cystitis. The …

CONDITION: Renal and Urogenital

GENDER: Females

AGE GROUP: 18 and above

TRIAL STATUS: Recruiting

HIV Research

OVERVIEW The Holdsworth House Research team are currently seeking volunteers for early stage research for HIV. There is no cost for study medication, and travel costs can be reimbursed. To …

CONDITION: Inflammatory and Immune System

GENDER: Both males and females

AGE GROUP: 18 and above

TRIAL STATUS: Recruiting

Gonorrhoea Clinical Study

Do you think you have Gonorrhoea? Gonorrhoea can cause serious health problems. A clinical research study for gonorrhoea may be an option for you. You may qualify for this no-cost …

CONDITION:

GENDER: Both males and females

AGE GROUP: 18 and above

TRIAL STATUS: Recruiting

Migraine Clinical Study

OVERVIEW The Holdsworth House Research team are currently looking for study participants who suffer from Migraines. The investigational product may reduce number of headache days. There is no cost for …

CONDITION: Neurological

GENDER: Both males and females

AGE GROUP: 18 to 70 years

TRIAL STATUS: Recruiting

Meningococcal Vaccine Study

Have you been vaccinated against Meningococcal Disease? The Holdsworth House Research team are currently recruiting for a study using investigational vaccines against Meningococcal Disease. If you are aged 18-25, have …

CONDITION: Infection

GENDER: Both males and females

AGE GROUP: 18 to 25 years

TRIAL STATUS: Recruiting

Diabetes Type 2 Clinical Study

OVERVIEW The Holdsworth House Research team are currently seeking volunteers to trial a new possible Type 2 Diabetes therapy. We are seeking patients whose diabetes control could be improved. There …

CONDITION: Metabolic and Endocrine

GENDER: Both males and females

AGE GROUP: 18 and above

TRIAL STATUS: Recruiting

Herbal Medicine for Osteoarthritis of the Knee

Researchers at NICM Health Research Institute are seeking participants to join a clinical trial investigating the effectiveness and safety of an herbal medicine for the management of osteoarthritis of the …

CONDITION: Musculoskeletal

GENDER: Both males and females

AGE GROUP: 40 to 75 years

TRIAL STATUS: Closed: follow-up complete