Project Title: The Role of Neuroinflammation in Hypertension – Minocycline for Resitant for Hypertension: A Randomised, double-blind, placebo-controlled trial
The objective of this study is to establish whether or not in humans an association between the immune system, nervous system activation and blood pressure (BP) exists and whether a therapy that modulates the immune system results in a clinically meaningful BP reduction.
Over recent years evidence has accumulated to suggest that hypertension is at least in part an immune response to inflammation. Whether immune mechanisms are of relevance in human hypertension has not yet been adequately investigated. In this study we would like to fill this knowledge gap and to explore whether targeting of relevant immune mechanism with medications would potentially lower BP and/or beneficially impact the damage to certain organs often accompanied by hypertension. We will investigate the potential link between blood pressure, immune system mediated inflammatory processes, and sympathetic nervous system activity in human hypertension.
If you have any of the following below, you may be eligible for the trial!
- Uncontrolled hypertension on 3 or more blood pressure medications