N-acetylcysteine (NAC) in the treatment of Obsessive-Compulsive Disorder (OCD)


Mental Health


Both males and females


From 18

to 75 years



A 24-week, double blind placebo study investigating the effects of the amino acid ‘N-acetylcysteine’ (NAC) in Obsessive-Compulsive Disorder (OCD). This study will determine if NAC is an effective treatment for individuals with OCD.

This NHMRC funded study is currently enrolling participants at 3 trial sites – The University of Melbourne, University of Queensland and Western Sydney University. We aim to recruit 200 participants – the largest NAC trial for OCD to date.

Eligible participants will be randomised to receive NAC (2,000mg – 4,000mg per day) or placebo capsules alongside their treatment as usual for a period of 6 months. Monthly assessments with a research assistant at their designated trial site (approx. 60-90 mins) will determine if any improvements have occurred in OCD symptoms, as well as depression, anxiety and quality of life.


Clinical Trial Site:
Phone Number: 03) 8344 0189 Email: georgina.oliver@unimelb.edu.au Location: 2 Salisbury St, Richmond, Victoria, Australia Butterfield St, Herston, Queensland, Australia Westmead New South Wales, Australia

Studies Contact Form

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Approved By: TMC Research Ethics Committee              

Clinical Trial Registry Link: Click Here